A PHASE I OPEN-LABEL STUDY OF THE SAFETY AND EFFICACY OF APATINIB (RIVOCERANIB) ADMINISTERED TO PATIENTS WITH ADVANCED MALIGNANCIES TO IMPROVE SENSITIVITY TO PEMBROLIZUMAB IN THE SECOND- OR LATER-LINE SETTING (APPEASE)

Abstract Objective APPEASE is a phase I study to assess the safety, dosing, and efficacy of rivoceranib (a selective, small-molecule inhibitor of VEGFR2) in combination with pembrolizumab.We aimed to treat patients with metastatic malignancies who have progressed through at least first-line therapy, with pembrolizumab 200 mg every 3 weeks, as well

The article substantiates the need to diagnose the state of innovative development of enterprises in Kyiv.It is determined that the solution to the problems of destabilization of enterprises is seen primarily in the formation of a system of conceptual foundations for ensuring innovative development and its diagnostics.The prerequisites for diagnosi

The purpose of this research is to analyze the influence of consumer ethnocentrism and its antecedents - patriotism and cosmopolitanism on consumer domestic and foreign buying behavior in the emerging economy of Kazakhstan.This country poses an interesting question as to how the effects of attitudes and purchase behavior differ in the once controll

Abstract Background Laparoscopic cholecystectomy (LC) for difficult acute cholecystitis (AC) cases bears a high risk of vasculobiliary injuries (VBI).The Tokyo Guidelines 2018 (TG18) recommend the use of bailout procedures and subtotal cholecystectomy to prevent VBI.Performing a safe LC is challenging, even when followed by an accurate pre-surgical

A new class of distribution is introduced here as a generalization of the well-known hyper-Poisson distribution of Bardwell and Crow (J.Amer.Statist.Associ., 1964) and alternative hyper-Poisson distribution of WOMAN BLACK COHOSH Kumar and Nair (Statistica, 2012), and derive some of its important aspects such as mean, variance, expressions for its r